Combining FLASH and spatially fractionated radiation therapy: The best of both worlds
- Author(s)
- Schneider, T; Fernandez-Palomo, C; Bertho, A; Fazzari, J; Iturri, L; Martin, OA; Trappetti, V; Djonov, V; Prezado, Y;
- Journal Title
- Radiotherapy and Oncology
- Publication Type
- Review
- Abstract
- FLASH radiotherapy (FLASH-RT) and spatially fractionated radiation therapy (SFRT) are two new therapeutical strategies that use non-standard dose delivery methods to reduce normal tissue toxicity and increase the therapeutic index. Although likely based on different mechanisms, both FLASH-RT and SFRT have shown to elicit radiobiological effects that significantly differ from those induced by conventional radiotherapy. With the therapeutic potential having been established separately for each technique, the combination of FLASH-RT and SFRT could therefore represent a winning alliance. In this review, we discuss the state of the art, advantages and current limitations, potential synergies, and where a combination of these two techniques could be implemented today or in the near future.
- Keywords
- Humans; *Dose Fractionation, Radiation; Radiotherapy Dosage; FLASH therapy; Normal tissue toxicity; Spatially fractionated radiation therapy
- Department(s)
- Radiation Oncology
- PubMed ID
- 35952978
- Publisher's Version
- https://doi.org/10.1016/j.radonc.2022.08.004
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-04-03 06:48:18
Last Modified: 2025-04-03 06:49:14