Circulating effector gammadelta T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals
- Author(s)
- von Borstel, A; Nguyen, TH; Rowntree, LC; Ashhurst, TM; Allen, LF; Howson, LJ; Holmes, NE; Smibert, OC; Trubiano, JA; Gordon, CL; Cheng, AC; Kent, SJ; Rossjohn, J; Kedzierska, K; Davey, MS;
- Details
- Publication Year 2023-04,Volume 101,Issue #4,Page 321-332
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Research article
- Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector gammadelta T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27(neg) CD45RA(+) CX3CR1(+) Vdelta1(effector) cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB(+) Vdelta2(+) T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the gammadelta T cell receptor repertoire of either Vdelta1(+) or Vdelta2(+) subsets. Our work demonstrates an association between effector populations of gammadelta T cells and acute COVID-19 in unvaccinated individuals.
- Publisher
- Wiley
- Keywords
- Humans; *T-Lymphocyte Subsets; Acute Disease; Receptors, Antigen, T-Cell, gamma-delta; *covid-19; SARS-CoV-2; Covid-19; Vdelta1 T cells; Vdelta2 T cells; gammadelta T cells
- Department(s)
- Infectious Diseases
- PubMed ID
- 36698330
- Publisher's Version
- https://doi.org/10.1111/imcb.12623
- Open Access at Publisher's Site
https://doi.org/10.1111/imcb.12623- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-08-07 07:16:21
Last Modified: 2023-08-07 07:17:40