Serial sensitive molecular detection of JAK2 V617F is predictive of relapse after allogeneic stem cell transplantation in patients with myelofibrosis

Author(s): Nedumannil, R; Karmi, T; Blombery, P; Szer, J; Ritchie, DS; Chee, LCY;
Details: Publication Year 2025-04,Volume 206,Issue #4,Page 1160-1164
Journal Title: British Journal of Haematology
Publication Type: Research article
Abstract: Relapse after allogeneic stem cell transplantation (alloSCT) represents a frequent complication in patients with myelofibrosis (MF). This retrospective study analysed 38 patients with JAK2-mutated MF who underwent alloSCT. Serial sensitive molecular assessments at regular intervals of JAK2 V617F revealed that a ≥2-fold increase in JAK2 variant allele frequency (VAF) at days +100 and +180 post-alloSCT was highly predictive of eventual morphological relapse. The integration of JAK2 VAF monitoring with chimerism analysis into post-alloSCT care represents a novel strategy for early detection of MF relapse, which may enable timely interventions and improve outcomes in such high-risk patients.
Publisher: Wiley
Keywords: Humans; *Janus Kinase 2/genetics; *Primary Myelofibrosis/genetics/therapy/diagnosis; Male; Middle Aged; Female; Retrospective Studies; Recurrence; Transplantation, Homologous; Adult; Aged; *Hematopoietic Stem Cell Transplantation; Gene Frequency; Mutation; molecular pathology; myelofibrosis; relapse; stem cell transplantation
Department(s): Haematology; Pathology
Publisher's Version: https://doi.org/10.1111/bjh.20003
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-03-21 04:37:01

Last Modified: 2025-05-15 04:17:35