Maintenance Therapy in AML: What Is the Future Potential?
- Author(s)
- Goulart, H; Wei, AH; Kadia, TM;
- Journal Title
- American Journal of Hematology
- Publication Type
- Review
- Abstract
- Over the last decade, there have been significant advancements in the treatment for patients with acute myeloid leukemia (AML) including the addition of novel, targeted agents to intensive or nonintensive chemotherapy regimens. However, despite this, the majority of patients will still ultimately relapse and long-term survival remains poor. While the use of maintenance therapy has emerged as a potential strategy to maintain more durable remissions and improve overall survival, the optimal use of these therapies has not yet been clearly defined. In this review, we provide a comprehensive overview of the evolution of maintenance strategies in AML and present a commentary on the future of maintenance therapy, including the pressing, unmet needs in this field.
- Publisher
- Wiley
- Keywords
- Humans; *Leukemia, Myeloid, Acute/drug therapy/mortality; *Maintenance Chemotherapy; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Remission Induction; Aml; AML molecular diagnosis and therapy; chemotherapy; leukemia
- Department(s)
- Haematology
- Publisher's Version
- https://doi.org/10.1002/ajh.27583
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-03-18 06:23:44
Last Modified: 2025-03-18 06:24:11