The Genetic Evolution of Metastasis
Details
Publication Year 2022-05-16,Volume 82,Issue #10,Page 1849-1857
Journal Title
Cancer Research
Publication Type
Review
Abstract
Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of metastases. In this review, we discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies.
Keywords
Evolution, Molecular; Genetic Heterogeneity; Humans; Mutation; Neoplasm Metastasis; *Neoplasms/genetics/pathology
Department(s)
Medical Oncology
PubMed ID
35476646
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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