The Genetic Evolution of Metastasis
- Author(s)
- Rogiers, A; Lobon, I; Spain, L; Turajlic, S;
- Details
- Publication Year 2022-05-16,Volume 82,Issue #10,Page 1849-1857
- Journal Title
- Cancer Research
- Publication Type
- Review
- Abstract
- Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of metastases. In this review, we discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies.
- Keywords
- Evolution, Molecular; Genetic Heterogeneity; Humans; Mutation; Neoplasm Metastasis; *Neoplasms/genetics/pathology
- Department(s)
- Medical Oncology
- PubMed ID
- 35476646
- Publisher's Version
- https://doi.org/10.1158/0008-5472.CAN-21-3863
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-03-07 05:57:23
Last Modified: 2025-03-07 06:00:21