International Validation of the EORTC QLQ-ANL27, a Field Study to Test the Anal Cancer-Specific Health-Related Quality-of-Life Questionnaire

Sodergren, SC; Johnson, CD; Gilbert, A; Darlington, AS; Cocks, K; Guren, MG; Rivin Del Campo, E; Brannan, C; Christensen, P; Chu, W; Chung, H; Dennis, K; Desideri, I; Gilbert, DC; Glynne-Jones, R; Jefford, M; Johansson, M; Johnsson, A; Juul, T; Kardamakis, D; Lai-Kwon, J; McFarlane, V; Miguel, IMC; Nugent, K; Peters, F; Riechelmann, RP; Turhal, NS; Wong, S; Vassiliou, V; European Organisation for Research and Treatment of Cancer Quality of Life Group

Author(s): Sodergren, SC; Johnson, CD; Gilbert, A; Darlington, AS; Cocks, K; Guren, MG; Rivin Del Campo, E; Brannan, C; Christensen, P; Chu, W; Chung, H; Dennis, K; Desideri, I; Gilbert, DC; Glynne-Jones, R; Jefford, M; Johansson, M; Johnsson, A; Juul, T; Kardamakis, D; Lai-Kwon, J; McFarlane, V; Miguel, IMC; Nugent, K; Peters, F; Riechelmann, RP; Turhal, NS; Wong, S; Vassiliou, V; European Organisation for Research and Treatment of Cancer Quality of Life Group;
Details: Publication Year 2023-04-01,Volume 115,Issue #5,Page 1155-1164
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Publication Type: Research article
Abstract: PURPOSE: The European Organisation for Research and Treatment of Cancer (EORTC) health-related quality of life questionnaire for anal cancer (QLQ-ANL27) supplements the EORTC cancer generic measure (QLQ-C30) to measure concerns specific to people with anal cancer treated with chemoradiotherapy. This study tested the psychometric properties and acceptability of the QLQ-ANL27. METHODS AND MATERIALS: People with anal cancer were recruited from 15 countries to complete the QLQ-C30 and QLQ-ANL27 and provide feedback on the QLQ-ANL27. Item responses, scale structure (multitrait scaling, factor analysis), reliability (internal consistency and reproducibility) and sensitivity (known group comparisons and responsiveness to change) of the QLQ-ANL27 were evaluated. RESULTS: Data from 382 people were included in the analyses. The EORTC QLQ-ANL27 was acceptable, comprehensive, and easy to complete, taking an average 8 minutes to complete. Psychometric analyses supported the EORTC QLQ-ANL27 items and reliability (Cronbach's alpha ranging from 0.71-0.93 and test-retest coefficients above 0.7) and validity of the scales (particularly nonstoma bowel symptoms and pain/discomfort). Most scales distinguished people according to treatment phase and performance status. Bowel (nonstoma), pain/discomfort, and vaginal symptoms were sensitive to deteriorations over time. The stoma-related scales remained untested because of low numbers of people with a stoma. Revisions to the scoring and question ordering of the sexual items were proposed. CONCLUSIONS: The QLQ-ANL27 has good psychometric properties and is available in 16 languages for people treated with chemoradiotherapy for anal cancer. It is used in clinical trials and has a potential role in clinical practice.
Publisher: Elsevier
Keywords: Female; Humans; Quality of Life; Reproducibility of Results; *Anus Neoplasms/radiotherapy; *Surgical Stomas; Surveys and Questionnaires; Psychometrics/methods
Department(s): Medical Oncology; Health Services Research
PubMed ID: 36402360
Publisher's Version: https://doi.org/10.1016/j.ijrobp.2022.11.002
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-08-07 07:16:16

Last Modified: 2023-08-07 07:17:40