Comparison of colorectal cancer outcomes in young adults and octogenarians
- Author(s)
- Prabhakaran, S; Kong, JC; Williams, E; Bell, S; Warrier, S; Simpson, P; Chin, M; Skinner, S; Carne, P;
- Details
- Publication Year 2022-05,Volume 223,Issue #5,Page 951-956
- Journal Title
- American Journal of Surgery
- Publication Type
- Research article
- Abstract
- BACKGROUND: This study aimed to characterise the outcomes associated with colorectal cancer (CRC), comparing young adults (<50 years), patients of screening age (50-79 years), and octogenarians (>80 years). METHODS: All consecutive CRC resections with curative intent were recruited into this study from a prospectively maintained CRC database at a tertiary academic centre. RESULTS: A total of 745 eligible cases were identified. Five-year survival in young adults was poorer than that of patients of screening age. Young adults had the highest incidence of rectal cancer resections, and presented with the most advanced tumour stages. Independent associations for poorer survival in young adults were increased nodal stage, the presence of distal metastases, and loss of MLH1/PMS2 staining on immunohistochemistry. Young adults had similar survival to octogenarians, when comparing patients treated with curative intent, regardless of oncological treatment.
- Keywords
- Aged; Aged, 80 and over; *Colorectal Neoplasms/pathology; Humans; Mass Screening; Middle Aged; Octogenarians; *Rectal Neoplasms; Retrospective Studies; Young Adult; Colorectal cancer; Young adults
- Department(s)
- Surgical Oncology; Laboratory Research
- PubMed ID
- 34399980
- Publisher's Version
- https://doi.org/10.1016/j.amjsurg.2021.08.013
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-03-06 11:08:01
Last Modified: 2025-03-06 11:25:09