Contrasting clinical characteristics and treatment patterns in women with newly diagnosed advanced-stage epithelial ovarian cancer in Australia, South Korea and Taiwan
- Author(s)
- Chou, HH; Fereday, S; DeFazio, A; Chang, CL; Bowtell, D; Hsu, HC; Traficante, N; Jeong, SY; Cheng, WF; Ariyarantne, D; Australian Ovarian Cancer Study Group; Tung, T; Rajadhyaksha, V; Lee, WH; Brown, D; Kim, BG;
- Journal Title
- Journal of Gynecologic Oncology
- Publication Type
- Research article
- Abstract
- OBJECTIVE: The real-world INFORM study analyzed sociodemographics, treatment patterns and clinical outcomes for patients with newly diagnosed advanced epithelial ovarian cancer (EOC) in Australia, South Korea (S.Korea) and Taiwan preceding incorporation of poly(ADP-ribose) polymerase inhibitors into clinical practice. METHODS: Retrospective data from patients diagnosed with EOC (high-grade serous EOC for Taiwan) between January 2014 and December 2018 with >/=12 months follow-up from diagnosis were analyzed descriptively. Survival was evaluated by Kaplan-Meier with two-sided 95% confidence interval (CI). RESULTS: Of the 987 patients (Australia, 223; S.Korea, 513; Taiwan, 251), 98% received platinum-based chemotherapy (CT). In S.Korea and Taiwan 76.0% and 78.9% respectively underwent primary cytoreductive surgery; in Australia, 56.5% had interval debulking surgery. Bevacizumab was included in primary/maintenance therapy for 22.4%, 14.6% and 6.8% of patients in Australia, S.Korea and Taiwan, respectively. Patients receiving bevacizumab were high-risk (reimbursement policy) and achieved similar real-world progression-free survival (PFS) compared with CT only. Overall, the median real-world PFS (months; 95% CI) was similar across Australia (16.0 [14.63-18.08]), S.Korea (17.7 [16.18-19.27]) and Taiwan (19.1 [17.56-22.29]). CONCLUSION: This study reveals poor prognosis despite differences in demographics and treatment patterns for patients with EOC across Asia-Pacific suggesting the need for biomarker-driven novel therapies to improve outcomes.
- Publisher
- Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, Japan Society of Gynecologic Oncology
- Keywords
- Humans; Female; Carcinoma, Ovarian Epithelial/drug therapy; *Ovarian Neoplasms/therapy/drug therapy; Bevacizumab/therapeutic use; Taiwan/epidemiology; Retrospective Studies; Neoadjuvant Therapy; Republic of Korea/epidemiology; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Cytoreduction Surgical Procedures
- Department(s)
- Laboratory Research
- PubMed ID
- 36366810
- Publisher's Version
- https://doi.org/10.3802/jgo.2023.34.e3
- Open Access at Publisher's Site
https://doi.org/10.3802/jgo.2023.34.e3- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-04-04 06:09:42
Last Modified: 2023-04-17 11:53:04