Non-autonomous regulation of neurogenesis by extrinsic cues: a Drosophila perspective
- Author(s)
- Nguyen, PK; Cheng, LY;
- Journal Title
- Oxford Open Neuroscience
- Publication Type
- Review
- Abstract
- The formation of a functional circuitry in the central nervous system (CNS) requires the correct number and subtypes of neural cells. In the developing brain, neural stem cells (NSCs) self-renew while giving rise to progenitors that in turn generate differentiated progeny. As such, the size and the diversity of cells that make up the functional CNS depend on the proliferative properties of NSCs. In the fruit fly Drosophila, where the process of neurogenesis has been extensively investigated, extrinsic factors such as the microenvironment of NSCs, nutrients, oxygen levels and systemic signals have been identified as regulators of NSC proliferation. Here, we review decades of work that explores how extrinsic signals non-autonomously regulate key NSC characteristics such as quiescence, proliferation and termination in the fly.
- Keywords
- neuroblast; Drosophila; niche
- Department(s)
- Laboratory Research
- PubMed ID
- 38596708
- Publisher's Version
- https://doi.org/10.1093/oons/kvac004
- Open Access at Publisher's Site
https://doi.org/10.1093/oons/kvac004- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 07:07:11
Last Modified: 2025-02-07 07:08:20