Current State of Neoadjuvant Radiotherapy for Rectal Cancer
- Details
- Publication Year 2022-03,Volume 21,Issue #1,Page 63-70
- Journal Title
- Clinical Colorectal Cancer
- Publication Type
- Review
- Abstract
- Colorectal cancer is the third most commonly diagnosed cancer, with rectal cancer accounting for 30% of cases. The current standard of care curative treatment for locally advanced rectal cancer is (chemo)radiotherapy followed by surgery and adjuvant chemotherapy. Although neoadjuvant radiotherapy has reduced the risk of local recurrence to less than 10%, the risk of distant metastasis remained high at 30% affecting patient survival. In addition, there is a recognition that there is heterogeneity in tumor biology and treatment response with good responders potentially suitable for treatment de-escalation. Therefore, new treatment sequencing and regimens were investigated. Here, we reviewed the evidence for current neoadjuvant treatment options in patients with locally advanced rectal adenocarcinoma, and highlight the new challenges in this new treatment landscape.
- Publisher
- Elsevier
- Keywords
- Chemoradiotherapy; Chemotherapy, Adjuvant; Humans; *Neoadjuvant Therapy; Neoplasm Recurrence, Local/epidemiology/pathology/prevention & control; Neoplasm Staging; *Rectal Neoplasms/radiotherapy; Biomarker; Locally advanced; Short course; Surgery
- Department(s)
- Radiation Oncology
- PubMed ID
- 34852972
- Publisher's Version
- https://doi.org/10.1016/j.clcc.2021.10.008
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 07:07:09
Last Modified: 2025-02-07 07:08:20