Extreme Thrombocytosis in Refractory ITP Post-Splenectomy With Associated Fatal Thromboembolism
- Author(s)
- Nedumannil, R; Leitinger, E; Juneja, S;
- Journal Title
- Clinical Pathology
- Publication Type
- Case report
- Abstract
- Thrombopoietin (TPO)-receptor agonists have heralded a paradigm shift in the treatment of refractory immune thrombocytopenia (ITP). Reactive thrombocytosis has been described as a secondary effect of such therapies. However, the phenomenon of extreme thrombocytosis with morphology mimicking a myeloproliferative neoplasm (MPN) followed by fatal thromboembolism is unusual in this setting. Caution is required in the diagnosis of refractory ITP as well as TPO-receptor agonist dosing in such cases.
- Publisher
- SAGE Publishing
- Keywords
- Purpura; idiopathic; receptors; splenectomy; thrombocytopenic; thrombocytosis; thromboembolism; thrombopoietin
- Department(s)
- Pathology
- PubMed ID
- 35284824
- Publisher's Version
- https://doi.org/10.1177/2632010X221083218
- Open Access at Publisher's Site
https://doi.org/10.1177/2632010x221083218- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 07:07:07
Last Modified: 2025-02-07 07:08:20