Consensus core clinical data elements for meningiomas (v2021.1)

Nassiri, F; Wang, JZ; Au, K; Barnholtz-Sloan, J; Jenkinson, MD; Drummond, K; Zhou, Y; Snyder, JM; Brastianos, P; Santarius, T; Suppiah, S; Poisson, L; Gaillard, F; Rosenthal, M; Kaufmann, T; Tsang, DS; Aldape, K; Zadeh, G

Author(s): Nassiri, F; Wang, JZ; Au, K; Barnholtz-Sloan, J; Jenkinson, MD; Drummond, K; Zhou, Y; Snyder, JM; Brastianos, P; Santarius, T; Suppiah, S; Poisson, L; Gaillard, F; Rosenthal, M; Kaufmann, T; Tsang, DS; Aldape, K; Zadeh, G;
Details: Publication Year 2022-05-04,Volume 24,Issue #5,Page 683-693
Journal Title: Neuro-Oncology
Publication Type: Guideline
Abstract: BACKGROUND: With increasing molecular analyses of meningiomas, there is a need to harmonize language used to capture clinical data across centers to ensure that molecular alterations are appropriately linked to clinical variables of interest. Here the International Consortium on Meningiomas presents a set of core and supplemental meningioma-specific common data elements (CDEs) to facilitate comparative and pooled analyses. METHODS: The generation of CDEs followed the 4-phase process similar to other National Institute of Neurological Disorders and Stroke (NINDS) CDE projects: discovery, internal validation, external validation, and distribution. RESULTS: The CDEs were organized into patient- and tumor-level modules. In total, 17 core CDEs (10 patient level and 7 tumor level) as well as 14 supplemental CDEs (7 patient level and 7 tumor level) were defined and described. These CDEs are now made publicly available for dissemination and adoption. CONCLUSIONS: CDEs provide a framework for discussion in the neuro-oncology community that will facilitate data-sharing for collaborative research projects and aid in developing a common language for comparative and pooled analyses. The meningioma-specific CDEs presented here are intended to be dynamic parameters that evolve with time and The Consortium welcomes international feedback for further refinement and implementation of these CDEs.
Keywords: *Biomedical Research; Consensus; Humans; *Meningeal Neoplasms; *Meningioma; National Institute of Neurological Disorders and Stroke (U.S.); United States; clinical trials; core data elements; meningioma; retrospective studies
Department(s): Medical Oncology
PubMed ID: 34791428
Publisher's Version: https://doi.org/10.1093/neuonc/noab259
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-02-07 07:02:34

Last Modified: 2025-02-07 07:06:52