PARP11 interfer(on)es with CAR T cell efficacy
- Author(s)
- Munoz, I; Beavis, PA;
- Details
- Publication Year 2022-07,Volume 3,Issue #7,Page 790-792
- Journal Title
- Nature Cancer
- Publication Type
- Commentary
- Abstract
- Despite the remarkable success of chimeric antigen receptor (CAR) T cell therapies in the treatment of hematological malignancies, this strategy remains challenging in solid tumors. One major obstacle is the hostile immunosuppressive tumor microenvironment. New research demonstrates that targeting PARP11 can overcome this immunosuppression and boost CAR T cell efcacy through stabilization of IFNAR1.
- Keywords
- *T-Lymphocytes
- Department(s)
- Laboratory Research
- PubMed ID
- 35883000
- Publisher's Version
- https://doi.org/10.1038/s43018-022-00406-w
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 05:05:37
Last Modified: 2025-02-07 05:08:50