Novel germline mutations for active surveillance and imaging strategies in prostate cancer
- Author(s)
- Mondschein, R; Taylor, R; Thorne, H; Bolton, D;
- Details
- Publication Year 2022-09-01,Volume 32,Issue #5,Page 456-461
- Journal Title
- Current Opinion in Urology
- Publication Type
- Review
- Abstract
- PURPOSE OF REVIEW: This review highlights the emerging role of genetics-lead medicine (GLM) in prostate cancer. We describe the benefits of GLM integration into prostate cancer screening, diagnosis and management. Imaging techniques enhancing prostate cancer detection are advancing concurrently, facilitating strategic active surveillance protocols for appropriately selected patients. We aim to improve clinician awareness of the role of GLM in current and future practice. RECENT FINDINGS: We explore recent literature advancing the role of GLM in prostate cancer detection and management, particularly as this coexists with the development of imaging technology. Our current understanding of germline mutations implicated in familial prostate cancer development is summarized. We describe how these developments are being utilized to inform screening, surveillance and the development of novel therapies. We summarize current guidelines and explore factors inhibiting optimal implementation of recommendations in clinical practice. SUMMARY: Integration and further development of genetics-lead medicine in the detection, surveillance and management of prostate cancer will improve clinical outcomes for men at risk of aggressive disease as a result of familial predispositions to prostate cancer. This review summarizes the pertinent developments in the field including improving clinician awareness to facilitate implantation of these strategies into current clinical practice.
- Keywords
- Early Detection of Cancer; Germ-Line Mutation; Humans; Male; Prostate-Specific Antigen; *Prostatic Neoplasms/diagnostic imaging/genetics; Watchful Waiting
- Department(s)
- Surgical Oncology; Laboratory Research
- PubMed ID
- 35855555
- Publisher's Version
- https://doi.org/10.1097/MOU.0000000000001024
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 03:35:39
Last Modified: 2025-02-07 03:38:02