Biomarkers in Locally Advanced Rectal Cancer: A Review

Author(s): Mendis, S; To, YH; Tie, J;
Details: Publication Year 2022-03,Volume 21,Issue #1,Page 36-44
Journal Title: Clinical Colorectal Cancer
Publication Type: Review
Abstract: Locally advanced rectal cancers (LARC) are the subject of a rapidly evolving treatment paradigm. The critical timepoints where management decisions are required during the care of the LARC patient are: prior to the institution of any treatment, post neoadjuvant therapy and post-surgery. This article reviews the clinical, imaging, blood-based, tissue-based, and molecular biomarkers that can assist clinicians at these timepoints in the patient's management, in prognosticating for their LARC patients or in predicting responses to therapy in the multi-modality neoadjuvant treatment era.
Keywords: Biomarkers; Chemoradiotherapy/methods; Humans; Neoadjuvant Therapy/methods; *Neoplasms, Second Primary/drug therapy; *Rectal Neoplasms/drug therapy/therapy; Rectum; Neoadjuvant chemoradiation; Prognosis; Rectal carcinoma; Survival; Treatment
Department(s): Medical Oncology
PubMed ID: 34961731
Publisher's Version: https://doi.org/10.1016/j.clcc.2021.11.002
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-01-31 07:02:48

Last Modified: 2025-01-31 07:03:46