Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: "What's Past Is Prologue" (Shakespeare)
- Author(s)
- Mato, AR; Davids, MS; Sharman, J; Roeker, LE; Kay, N; Kater, AP; Rogers, K; Thompson, MC; Rhodes, J; Goy, A; Skarbnik, A; Schuster, SJ; Tam, CS; Eyre, TA; O'Brien, S; Nabhan, C; Lamanna, N; Sun, C; Shadman, M; Pagel, JM; Ujjani, C; Brander, D; Coombs, CC; Jain, N; Cheah, CY; Brown, JR; Seymour, JF; Woyach, JA;
- Details
- Publication Year 2022-02-15,Volume 28,Issue #4,Page 603-608
- Journal Title
- Clinical Cancer Research
- Publication Type
- Review
- Abstract
- The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented changes over the last decade. Modern targeted therapies are incorporated into clinical practice. Unfortunately, patients have begun to develop resistance or intolerance to multiple classes. Symptomatic patients previously treated with a BTK inhibitor (BTKi) and venetoclax represent a new and rapidly growing unmet need in CLL. Here, we define unmet needs in a modern treatment context. We also critically review the literature for PI3K inhibitors and chemoimmunotherapy and lack of data to support their utility following BTKis and venetoclax. Finally, we suggest opportunities to ensure the continued innovation for patients with CLL.
- Keywords
- Humans; Immunotherapy; *Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors/pharmacology/therapeutic use
- Department(s)
- Haematology
- PubMed ID
- 34789482
- Publisher's Version
- https://doi.org/10.1158/1078-0432.CCR-21-1237
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-31 03:38:59
Last Modified: 2025-01-31 03:40:50