A metabolic pathway for improving adoptive cellular therapy
- Author(s)
- Scheffler, CM; Beavis, PA; Darcy, PK;
- Details
- Publication Year 2025-01-13,Volume 43,Issue #1,Page 8-10
- Journal Title
- Cancer Cell
- Publication Type
- Commentary
- Abstract
- In this issue of Cancer Cell, Qiu et al. use single-cell metabolic analysis to identify reduced mannose metabolism as a previously unknown feature of exhausted T cells. This metabolic pathway can be targeted to enhance memory and persistence of adoptively transferred T cells, resulting in improved anti-tumor efficacy.
- Publisher
- Cell Press
- Keywords
- Humans; *Immunotherapy, Adoptive/methods; Metabolic Networks and Pathways; T-Lymphocytes/immunology/metabolism; Neoplasms/therapy/immunology/metabolism; Animals; Mannose/metabolism
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.1016/j.ccell.2024.11.014
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-28 02:54:22
Last Modified: 2025-01-28 02:54:47