A metabolic pathway for improving adoptive cellular therapy
Details
Publication Year 2025-01-13,Volume 43,Issue #1,Page 8-10
Journal Title
Cancer Cell
Publication Type
Commentary
Abstract
In this issue of Cancer Cell, Qiu et al. use single-cell metabolic analysis to identify reduced mannose metabolism as a previously unknown feature of exhausted T cells. This metabolic pathway can be targeted to enhance memory and persistence of adoptively transferred T cells, resulting in improved anti-tumor efficacy.
Publisher
Cell Press
Keywords
Humans; *Immunotherapy, Adoptive/methods; Metabolic Networks and Pathways; T-Lymphocytes/immunology/metabolism; Neoplasms/therapy/immunology/metabolism; Animals; Mannose/metabolism
Department(s)
Laboratory Research
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2025-01-28 02:54:22
Last Modified: 2025-01-28 02:54:47
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