Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer
- Author(s)
- Loi, S; Salgado, R; Adams, S; Pruneri, G; Francis, PA; Lacroix-Triki, M; Joensuu, H; Dieci, MV; Badve, S; Demaria, S; Gray, R; Munzone, E; Drubay, D; Lemonnier, J; Sotiriou, C; Kellokumpu-Lehtinen, PL; Vingiani, A; Gray, K; Andre, F; Denkert, C; Piccart, M; Roblin, E; Michiels, S;
- Journal Title
- NPJ Breast Cancer
- Publication Type
- Research article
- Abstract
- The importance of integrating biomarkers into the TNM staging has been emphasized in the 8(th) Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8(th) edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.
- Publisher
- Nature Portfolio
- Department(s)
- Medical Oncology; Laboratory Research
- PubMed ID
- 35017545
- Publisher's Version
- https://doi.org/10.1038/s41523-021-00362-1
- Open Access at Publisher's Site
https://doi.org/10.1038/s41523-021-00362-1- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-24 05:57:05
Last Modified: 2025-01-24 05:58:22