Time-to-positivity in bloodstream infection for Candida species as a prognostic marker for mortality
- Author(s)
- Keighley, C; Pope, AL; Marriott, D; Chen, SC; Slavin, MA; Australia and; New Zealand Mycoses Interest Group;
- Details
- Publication Year 2023-04-03,Volume 61,Issue #4,Page myad028
- Journal Title
- Medical Mycology
- Publication Type
- Research article
- Abstract
- Time-to-positivity (TTP) may assist in predicting the outcome of candidaemia. We analysed a candidaemia dataset collected prospectively in Australia over 1 year (2014-2015). TTP was defined as the period from blood culture sampling to the blood culture flagging positive. Of 415 candidaemia episodes, overall, 30-day mortality was 29% (120/415); mortality with Candida albicans was 35% (59/169), C. glabrata complex, 37% (43/115), C. tropicalis, 43% (10/23), Pichia kudriavzevii 25% (3/12), and C. parapsilosis complex 7% (5/71). Each day of increased TTP multiplied the odds ratio (OR) of survival at 30 days by a factor of 1.32 [95% confidence interval (CI) 1.06-1.69]. Shorter TTP was associated with increased mortality, with 1-day TTP associated with 30-day mortality 37% (41/112) (95%CI: 28%-46%) and 5-day TTP 11% (2/18) (95%CI: 2%-36%).; Time-to-positivity is a measure that is available to clinicians when patients are identified as having candida in their bloodstream. Our data support the association of a shorter time to positivity with higher mortality.; eng
- Publisher
- Oxford University Press
- Keywords
- Animals; *Candida; Prognosis; *Candidemia/drug therapy/veterinary; Candida glabrata; Candida albicans; Candida tropicalis; Candida parapsilosis; Antifungal Agents/therapeutic use; candidaemia; bloodstream infection; candida; mortality; time to positivity
- Department(s)
- Infectious Diseases
- PubMed ID
- 37019819
- Publisher's Version
- https://doi.org/10.1093/mmy/myad028
- Open Access at Publisher's Site
https://doi.org/10.1093/mmy/myad028- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-07-27 08:03:03
Last Modified: 2023-07-27 08:03:33