Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients
- Author(s)
- Li, Z; Le Roux, PY; Callahan, J; Hardcastle, N; Hofman, MS; Siva, S; Yamamoto, T;
- Journal Title
- Physics and Imaging in Radiation Oncology
- Publication Type
- Research article
- Abstract
- Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 ((68)Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (D(LCO)). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26-0.88). (68)Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with D(LCO) (</=0.59). Our findings suggested that (68)Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.
- Publisher
- Elsevier
- Keywords
- Lung cancer; Lung function; Positron emission tomography/computed tomography (PET/CT); Ventilation/perfusion
- Department(s)
- Cancer Imaging; Physical Sciences; Radiation Oncology
- PubMed ID
- 35465222
- Publisher's Version
- https://doi.org/10.1016/j.phro.2022.03.005
- Open Access at Publisher's Site
https://doi.org/10.1016/j.phro.2022.03.005- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-17 07:00:17
Last Modified: 2025-01-17 07:03:10