A Systematic Review Into the Radiologic Features Predicting Local Recurrence After Stereotactic Ablative Body Radiotherapy (SABR) in Patients With Non-Small Cell Lung Cancer (NSCLC)

Lee, K; Le, T; Hau, E; Hanna, GG; Gee, H; Vinod, S; Dammak, S; Palma, D; Ong, A; Yeghiaian-Alvandi, R; Buck, J; Lim, R

Author(s): Lee, K; Le, T; Hau, E; Hanna, GG; Gee, H; Vinod, S; Dammak, S; Palma, D; Ong, A; Yeghiaian-Alvandi, R; Buck, J; Lim, R;
Details: Publication Year 2022-05-01,Volume 113,Issue #1,Page 40-59
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Publication Type: Review
Abstract: PURPOSE: Posttreatment surveillance for local recurrence (LR) after stereotactic ablative body radiotherapy (SABR) can include both fluorodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT). Radiation-induced lung injury shares a similar appearance to LR after treatment, making the detection of LR on imaging difficult for clinicians. We aimed to summarize radiologic features of CT and FDG-PET predicting LR and to evaluate radiomics as another tool for detecting LR. METHODS AND MATERIALS: We searched MEDLINE, EMBASE, and PubMed databases for published studies and Web of Science, Wiley Online, and Science Direct databases for conference abstracts that had patient populations with non-small cell lung cancer and reported post-SABR radiologic features of FDG-PET or CT and radiomics from either FDG-PET or CT. Studies for inclusion were independently reviewed by 2 authors. RESULTS: Across 32 relevant studies, the incidence of LR was 13% (222/1726). On CT, certain gross radiologic appearances and kinetic features of changes in size, diameter, volume, or 3 consecutive rises in volume of masslike consolidation are suggestive of LR. **Particular regard should be made for the presence of any >/=3 high-risk features on CT or the individual high-risk features of enlarging opacity at >/=12 month's post-SABR as being highly suspicious of LR. On FDG-PET a relative reduction of <5% of maximum standardised uptake value (SUV(max)) from baseline in the first 12 months or cut-offs of SUV(max) >5 and SUV(mean) >3.44 after 12 months can indicate LR. There is limited evidence available to corroborate radiomic features suggestive of LR. CONCLUSIONS: This research has identified common features of LR compared with radiation-induced lung injury, which may aid in early and accurate detection of LR post-SABR; further research is required to validate these findings.
Publisher: Elsevier
Keywords: *Carcinoma, Non-Small-Cell Lung/diagnostic imaging/radiotherapy/surgery; Fluorodeoxyglucose F18; Humans; *Lung Injury; *Lung Neoplasms/diagnostic imaging/radiotherapy; Positron-Emission Tomography/methods; *Radiation Injuries; *Radiosurgery/adverse effects/methods
Department(s): Radiation Oncology
PubMed ID: 34879247
Publisher's Version: https://doi.org/10.1016/j.ijrobp.2021.11.027
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-01-17 02:00:44

Last Modified: 2025-01-17 02:02:19