What's Current and What's New in Mesothelioma?
- Details
- Publication Year 2022-11,Volume 34,Issue #11,Page 771-780
- Journal Title
- Clinical Oncology
- Publication Type
- Review
- Abstract
- Malignant mesothelioma is a rare disease with limited treatment options. In malignant pleural mesothelioma (MPM), radical trimodality approaches, including surgery, radiotherapy and systemic chemo- and immunotherapy, have been delivered in some countries but remain controversial due to a lack of randomised evidence. Even in the unresectable scenario, surgery and radiotherapy play an important role in managing pleural effusions and pain, which may optimise wellbeing and maintain performance status. From the systemic treatment point of view, the recent incorporation of anti-angiogenics and, more importantly, immunotherapy has changed the standard of care in a space where chemotherapy with platinum and pemetrexed was the only therapeutic intervention with demonstrated benefits in overall survival. Histology is essential in determining an initial treatment plan as non-epithelioid MPMs may have a higher substantial survival improvement with dual immunotherapy compared with chemotherapy, whereas chemotherapy remains an option for epithelioid MPM; however, predictive biomarkers for systemic therapy are not entirely validated to guide the selection, as a subgroup of MPM patients might not benefit from immunotherapy. This overview approaches how the overall management of mesothelioma is evolving to incorporate the recent changes in the standards of care.
- Publisher
- Elsevier
- Keywords
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Combined Modality Therapy; Humans; *Lung Neoplasms; *Mesothelioma/drug therapy; *Mesothelioma, Malignant/therapy; Pemetrexed/therapeutic use; Platinum/therapeutic use; *Pleural Neoplasms/drug therapy/pathology; Chemotherapy; immune checkpoint inhibitors; immunotherapy; malignant pleural mesothelioma; mesothelioma radiotherapy; mesothelioma surgery
- Department(s)
- Medical Oncology; Radiation Oncology
- PubMed ID
- 36155156
- Publisher's Version
- https://doi.org/10.1016/j.clon.2022.08.029
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-17 02:00:42
Last Modified: 2025-01-17 02:02:19