Prevalence of malnutrition and nutrition-related complications in patients with gastroenteropancreatic neuroendocrine tumours

Laing, E; Gough, K; Krishnasamy, M; Michael, M; Kiss, N

Author(s): Laing, E; Gough, K; Krishnasamy, M; Michael, M; Kiss, N;
Details: Publication Year 2022-06,Volume 34,Issue #6,Page e13116
Journal Title: Journal of Neuroendocrinology
Publication Type: Research article
Abstract: Cross-sectional studies report that up to 25% of people with gastroenteropancreatic neuroendocrine tumours (GEP NET) are malnourished. However, the changes in nutritional status and dietary intake over time are unknown. The present study aimed to comprehensively describe the impact of a GEP NET on nutritional status and quality of life (QOL). Patients diagnosed with a GEP NET were recruited to this prospective longitudinal study on initial attendance to the NET Unit at two tertiary hospitals in Melbourne (VIC, Australia). Patient self-reported QOL measures (European Organisation for Research and Treatment Cancer QLC-C30 and QLC-GINET21) and nutritional outcomes (nutritional status, weight change, fat-free mass [FFM], dietary change, dietitian contact) were collected bi-monthly for six months. Sixty-one patients were recruited (66% male) with a mean +/- SD age of 62 +/- 12 years, predominantly diagnosed with small intestinal NET and Grade 1/2 disease. Commonly reported symptoms were fatigue (79%), abdominal discomfort (75%) and pain (68%). More patients were malnourished at baseline than at 6 months (29% vs. 13%). Over this 6 months, 48% lost weight, 20% lost >/= 5% of their body weight, and 62% lost FFM with an average FFM loss of 2.8 kg (95% confidence interval = 2.0, 3.6), consistent with altered body composition. Dietary change was reported by 56% at baseline and 53% at six months, but only 21% consulted a dietitian at baseline and 18% at 6 months. Clinically significant loss of weight and FFM affected many patients with a GEP NET; however, few patients were referred to/or received a consultation with a dietitian. Valid screening practices are needed to identify weight loss and nutrition issues in GEP NET patients, and to facilitate referral to dietitian services.
Publisher: Wiley
Keywords: Aged; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; *Malnutrition/diagnosis/epidemiology/etiology; Middle Aged; *Neuroendocrine Tumors/complications/epidemiology; Nutritional Status; Prevalence; Prospective Studies; Quality of Life; Weight Loss; diet; malnutrition; neuroendocrine tumor; nutrition
Department(s): Nutrition and Speech Pathology; Health Services Research; Academic Nursing; Medical Oncology
PubMed ID: 35415851
Publisher's Version: https://doi.org/10.1111/jne.13116
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-01-09 06:52:42

Last Modified: 2025-01-09 06:54:51