Do CYP2D6 genotypes affect oxycodone dose, pharmacokinetics, pain, and adverse effects in cancer?

Wong, AK; Vogrin, S; Klepstad, P; Rubio, J; Le, B; Philip, J; Somogyi, AA

Author(s): Wong, AK; Vogrin, S; Klepstad, P; Rubio, J; Le, B; Philip, J; Somogyi, AA;
Details: Publication Year 2024,Volume 25,Issue #14-15,Page 579-586
Journal Title: Pharmacogenomics
Publication Type: Research article
Abstract: AIMS: To examine the associations between CYP2D6 and CYP3A4 polymorphisms, plasma oxycodone and metabolite concentrations, and oxycodone response (dose, pain scores, and adverse effects) in people with pain from advanced cancer. PATIENTS & METHODS: This multi-center prospective cohort study included clinical data, questionnaires (pain and adverse effects), and blood (pharmacokinetics, DNA). Negative binomial regression and logistic regression were used. RESULTS: Within 33 participants, there were no differences in oxycodone response between CYP2D6 intermediate/poor metabolisers compared to normal metabolisers.Higher plasma noroxycodone and noroxycodone/oxycodone concentration ratios had higher odds of uncontrolled average pain (OR 2.44 (95%CI 1.00-5.95), p = 0.05 and OR 10.48 (95%CI 1.42-77.15), p = 0.02, respectively). CONCLUSIONS: There was no observed benefit in CYP2D6 genotyping in oxycodone response, however monitoring noroxycodone and oxymorphone concentrations warrant further examination.
Publisher: Taylor & Francis
Keywords: Humans; *Oxycodone/pharmacokinetics/adverse effects/administration & dosage; *Cytochrome P-450 CYP2D6/genetics; Female; Male; *Genotype; Middle Aged; *Analgesics, Opioid/pharmacokinetics/adverse effects/administration & dosage; Aged; *Neoplasms/genetics/drug therapy; Prospective Studies; Cancer Pain/drug therapy/genetics; Cytochrome P-450 CYP3A/genetics; Adult; Dose-Response Relationship, Drug; Morphinans; Opioid; advanced cancer; analgesics; palliative care; pharmacogenetics
Department(s): Palliative Care
Publisher's Version: https://doi.org/10.1080/14622416.2024.2430161
Open Access at Publisher's Site: https://doi.org/10.1080/14622416.2024.2430161
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-01-09 06:35:17

Last Modified: 2025-05-22 12:57:34