Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia
- Author(s)
- Loo, S; Potter, N; Ivey, A; O'Nions, J; Moon, R; Jovanovic, J; Fong, CY; Anstee, NS; Tiong, IS; Othman, J; Chua, CC; Renshaw, H; Baker, R; Fleming, S; Russell, NH; Ritchie, D; Bajel, A; Hou, HA; Dillon, R; Wei, AH;
- Details
- Publication Year 2024-12-12,Volume 144,Issue #24,Page 2554-2557
- Journal Title
- Blood
- Publication Type
- Research article
- Abstract
- Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).
- Publisher
- American Society of Hematology
- Keywords
- Humans; *Myeloid-Lymphoid Leukemia Protein/genetics; *Neoplasm, Residual/diagnosis/genetics; *Histone-Lysine N-Methyltransferase/genetics; *Leukemia, Myeloid, Acute/genetics/mortality/diagnosis; Prognosis; Male; Middle Aged; Female; Adult; Gene Rearrangement; Aged; Hematopoietic Stem Cell Transplantation; Oncogene Proteins, Fusion/genetics; Young Adult; Adolescent
- Department(s)
- Haematology; Pathology
- Publisher's Version
- https://doi.org/10.1182/blood.2024026605
- Open Access at Publisher's Site
https://doi.org/10.1182/blood.2024026605- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-07 06:20:54
Last Modified: 2025-01-07 06:21:10