Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study
- Author(s)
- Han, WM; Sazzad, HMS; Bloch, M; Baker, DA; Roth, N; Bowden-Reid, E; Smith, DE; Hoy, JF; Woolley, I; Finlayson, R; Templeton, DJ; Matthews, GV; Costello, J; Dawson, MA; Dawson, SJ; Polizzotto, MN; Petoumenos, K; Yeh, P; Dharan, NJ; ARCHIVE Study Group;
- Journal Title
- Cell Reports Medicine
- Publication Type
- Research article
- Abstract
- While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient -2.18, 95% CI -3.92, -0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.
- Publisher
- Cell Press
- Keywords
- Hiv; aging-related comorbidities; clonal hematopoiesis; frailty; geriatric syndromes; multimorbidity; phenotypic age acceleration; quality of life
- Department(s)
- Haematology
- Publisher's Version
- https://doi.org/10.1016/j.xcrm.2024.101835
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-07 03:38:12
Last Modified: 2025-01-07 03:42:55