Stereotactic ablative radiotherapy for primary kidney cancer - An international patterns of practice survey
- Author(s)
- Taplin, K; Hannan, R; Lo, SS; Morgan, SC; Ali, M; Sigurdson, S; Guckenberger, M; Swaminath, A;
- Journal Title
- Clinical and Translational Radiation Oncology
- Publication Type
- Research article
- Abstract
- PURPOSE: To conduct an international survey of radiation oncologists treating primary renal cell carcinoma (RCC) with SABR to ascertain the general patterns of SABR use, common dose/treatment/follow-up details, and expected outcomes. MATERIALS AND METHODS: A 51-question survey was created containing the following themes: prevalence and clinical scenarios in which RCC SABR is used, dose-fractionation schedules, treatment delivery details, follow-up/outcome assessments, and implementation barriers. The survey was distributed widely across multiple influential radiation oncology societies and social media, and ran from January to April 2023. RESULTS: A total of 255 respondents participated, mostly from academic centers within Europe/North America. Of these, 40 % (n = 102) currently offer SABR (50 % having begun within the last 3 years). Common barriers in non-users included lack of referrals by urologists and lack of supportive practice guidelines. Of respondents who do offer SABR, 77 % treat both small (4 cm or less) and large (>4 cm) renal masses. Dose-fractionation strategies varied from 27-52 Gy (3-5 fractions) for multifraction regimens, and 15-34 Gy for single fractions. Apart from treatment for medically inoperable disease, scenarios in which SABR was likely to be offered were for recurrence post surgery/thermal ablation and for oligometastatic kidney lesions. Uncommon scenarios included RCC with renal vein/inferior vena cava thrombosis, and as cytoreductive therapy in metastatic RCC. Expected local control outcomes were generally above 70 %, higher for small versus large renal masses. CONCLUSIONS: SABR is a relatively newer indication for primary RCC, offered by less than 50% of respondents, with both consistent and variable practice patterns observed.
- Publisher
- Elsevier
- Keywords
- Kidney cancer; Practice patterns; Rcc; Stereotactic radiation; Survey
- Department(s)
- Radiation Oncology
- Publisher's Version
- https://doi.org/10.1016/j.ctro.2024.100891
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-01-07 12:54:51
Last Modified: 2025-01-07 01:03:05