Nutrition support use and clinical outcomes in patients with multiple myeloma undergoing autologous stem cell transplant

Kuypers, J; Simmance, N; Quach, H; Hastie, K; Kiss, N

Author(s): Kuypers, J; Simmance, N; Quach, H; Hastie, K; Kiss, N;
Details: Publication Year 2022-11,Volume 30,Issue #11,Page 9341-9350
Journal Title: Supportive Care in Cancer
Publication Type: Research article
Abstract: PURPOSE: Malnutrition is associated with worse outcomes post-haematopoietic stem cell transplantation, with nutrition support recommended for people who are malnourished or have prolonged inadequate energy intake. We investigated associations between nutritional status, nutrition support type and clinical outcomes in adults with multiple myeloma post stem cell transplantation. METHODS: Medical records (2015-2020) were reviewed to retrieve demographics, anthropometry, dietary data, nutrition support type (enteral/oral versus parenteral), and clinical outcomes (engraftment time, infection, length of stay, weight changes). Relationships were examined using linear regression modelling and Fisher's exact test. RESULTS: One hundred thirteen participants were included (61% male; median age 62 years). Fifteen participants (13%) received parenteral and 98 (87%) received enteral/oral nutrition support. Parenteral nutrition was associated with shorter platelet engraftment time by 2.7 days (p = 0.036) and a longer hospital stay by 6.1 days (p < 0.001). Nutrition support was not associated with neutrophil engraftment time (p = 0.365). Inadequate energy intake for >/= 7 days was not associated with any clinical outcomes (p > 0.05). CONCLUSIONS: Participants who received parenteral nutrition reached platelet engraftment sooner but were in hospital longer. Inadequate energy intake for >/= 7 days did not impact clinical outcomes. Multi-site prospective studies are warranted to confirm results.
Publisher: Springer Nature
Keywords: Adult; Humans; Male; Middle Aged; Female; *Multiple Myeloma/therapy; *Hematopoietic Stem Cell Transplantation; Parenteral Nutrition/methods; Nutritional Support; *Malnutrition/etiology/therapy; Stem Cell Transplantation; Autologous stem cell transplant; Enteral nutrition; Multiple myeloma; Nutrition support; Parenteral nutrition
Department(s): Nutrition and Speech Pathology
PubMed ID: 36089605
Publisher's Version: https://doi.org/10.1007/s00520-022-07358-y
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-12-20 06:37:17

Last Modified: 2024-12-20 06:39:29