Regulation of gene expression via translational buffering
- Author(s)
- Kusnadi, EP; Timpone, C; Topisirovic, I; Larsson, O; Furic, L;
- Details
- Publication Year 2022-01,Volume 1869,Issue #1,Page 119140
- Journal Title
- Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research
- Publication Type
- Review
- Abstract
- Translation of an mRNA represents a critical step during the expression of protein-coding genes. As mechanisms governing post-transcriptional regulation of gene expression are progressively unveiled, it is becoming apparent that transcriptional programs are not fully reflected in the proteome. Herein, we highlight a previously underappreciated post-transcriptional mode of regulation of gene expression termed translational buffering. In principle, translational buffering opposes the impact of alterations in mRNA levels on the proteome. We further describe three types of translational buffering: compensation, which maintains protein levels e.g. across species or individuals; equilibration, which retains pathway stoichiometry; and offsetting, which acts as a reversible mechanism that maintains the levels of selected subsets of proteins constant despite genetic alteration and/or stress-induced changes in corresponding mRNA levels. While mechanisms underlying compensation and equilibration have been reviewed elsewhere, the principal focus of this review is on the less-well understood mechanism of translational offsetting. Finally, we discuss potential roles of translational buffering in homeostasis and disease.
- Publisher
- Elsevier
- Keywords
- Animals; Codon Usage; *Homeostasis; Humans; *Protein Biosynthesis; RNA Processing, Post-Transcriptional; Ribosomal Proteins/metabolism; Posttranscriptional regulation; Translational buffering; Translational offsetting; mRNA translation; tRNA epitranscriptomics
- Department(s)
- Laboratory Research
- PubMed ID
- 34599983
- Publisher's Version
- https://doi.org/10.1016/j.bbamcr.2021.119140
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-12-20 06:37:16
Last Modified: 2024-12-20 06:39:29