Key informant perspectives on implementing genomic newborn screening: a qualitative study guided by the Action, Actor, Context, Target, Time framework

Tutty, E; Archibald, AD; Downie, L; Gaff, C; Lunke, S; Vears, DF; Stark, Z; Best, S

Author(s): Tutty, E; Archibald, AD; Downie, L; Gaff, C; Lunke, S; Vears, DF; Stark, Z; Best, S;
Details: Publication Year 2024-12,Volume 32,Issue #12,Page 1599-1605
Journal Title: European Journal of Human Genetics
Publication Type: Research article
Abstract: Newborn screening (NBS) programmes are highly successful, trusted, public health interventions. Genomic sequencing offers the opportunity to increase the benefits of NBS by screening infants for a greater number and variety of childhood-onset conditions. This study aimed to describe who needs to do what, when, and for whom to deliver genomic newborn screening (gNBS) and capture perceived implementation barriers and enablers. 'Key informants' (individuals involved in the delivery of NBS) were interviewed. The Actor, Action, Context, Time and Target framework guided data collection and analysis. Participants (N = 20) identified new Actions required to deliver gNBS (educating healthcare providers, longitudinal psychosocial support), NBS Actions needing modification (obtaining consent) and NBS Actions that could be adopted for gNBS (prompt referral pathways). Obtaining consent in a prenatal Context was a source of some disagreement. The Time to disclose high chance results was raised as a key consideration in gNBS programme design. Genetic counsellors were identified as key Actors in results management, but workforce limitations may be a barrier. Online decision support tools were an enabler to offering gNBS. The implementation of gNBS will require behaviour changes from HCPs delivering NBS. Findings can inform how to deliver gNBS at population-scale.
Publisher: Springer Nature
Keywords: Humans; *Neonatal Screening/methods; Infant, Newborn; *Genetic Testing/methods; Female; Male; Qualitative Research; Genetic Counseling/psychology/methods; Adult
Department(s): Health Services Research
Publisher's Version: https://doi.org/10.1038/s41431-024-01650-7
Open Access at Publisher's Site: https://doi.org/10.1038/s41431-024-01650-7
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-12-19 06:00:48

Last Modified: 2024-12-19 06:01:06