Emerging concepts of CMV in transplantation
Details
Publication Year 2025-01,Volume 55,Issue #1,Page 12-19
Journal Title
Internal Medicine Journal
Publication Type
Review
Abstract
Cytomegalovirus (CMV) infections continue to be associated with significant morbidity and mortality following solid organ transplantation and haemopoietic stem cell transplantation. Advances in understanding the biology of CMV in the immunosuppressed host will translate into improved management approaches and better clinical outcomes. Updated definitions of resistant and refractory CMV infections will lead to more consistent reporting of CMV outcomes, better inform appropriate antiviral strategies and influence clinical trial design. Improved knowledge of the immunological control of CMV in the immunosuppressed host has led to novel diagnostics, emerging therapeutic cellular therapies and the development of an informed rationale for prophylactic and pre-emptive strategies. As the boundaries of transplantation are extended, new patterns of CMV infection are being recognised. Finally, recent studies support the use of novel antiviral therapies in transplant recipients in the appropriate clinical setting. In this review, we provide an update on important new and emerging concepts in the management of CMV in immunosuppressed transplant recipients.
Publisher
Wiley
Keywords
Humans; *Cytomegalovirus Infections/immunology/diagnosis/therapy/drug therapy/prevention; & control/etiology/epidemiology; Antiviral Agents/therapeutic use; *Immunocompromised Host/immunology; *Cytomegalovirus/immunology; *Organ Transplantation/adverse effects/trends; *Hematopoietic Stem Cell Transplantation/adverse effects; Immunosuppressive Agents/adverse effects; cytomegalovirus; immune monitoring; organ transplantation; resistance; stem cell transplantation
Department(s)
Haematology
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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