Impact of chronic lymphocytic leukaemia on melanoma outcomes: A retrospective case-control study

Author(s): Jobson, D; McCormack, CJ; Mar, V; Tam, C; Henderson, MA;
Details: Publication Year 2022-05,Volume 197,Issue #3,Page 320-325
Journal Title: British Journal of Haematology
Publication Type: Research article
Abstract: With new, effective treatments for chronic lymphocytic leukaemia (CLL) the impact of second malignancies is increasingly important. We performed a retrospective case-controlled study examining the effect of CLL and its treatment on melanoma-specific survival and recurrence. A total of 56 patients with melanoma with CLL were matched 1:1 to patients without CLL for age, date of diagnosis, gender and melanoma tumour, node, metastasis (TNM) stage. Multivariate analysis found CLL was associated with significantly worse melanoma-specific mortality (hazard ratio [HR] 2.46, 95% confidence interval [CI] 1.27-4.74, p = 0.007) and recurrence (HR 3.44, 95% CI 1.79-6.63, p < 0.001). Patients with CLL had poor immunotherapy tolerance and prior CLL treatment was not associated with melanoma outcomes.
Keywords: Case-Control Studies; Humans; *Leukemia, Lymphocytic, Chronic, B-Cell; *Melanoma/therapy; *Neoplasms, Second Primary; Retrospective Studies; chronic lymphocytic leukaemia; melanoma; recurrence; survival; treatment
Department(s): Surgical Oncology; Haematology
PubMed ID: 35286715
Publisher's Version: https://doi.org/10.1111/bjh.18090
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-12-19 03:18:21

Last Modified: 2024-12-19 03:23:08