Exosomes at the crossroad between therapeutic targets and therapy resistance in head and neck squamous cell carcinoma

Jangholi, A; Muller Bark, J; Kenny, L; Vasani, S; Rao, S; Dolcetti, R; Punyadeera, C

Author(s): Jangholi, A; Muller Bark, J; Kenny, L; Vasani, S; Rao, S; Dolcetti, R; Punyadeera, C;
Details: Publication Year 2022-09,Volume 1877,Issue #5,Page 188784
Journal Title: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Publication Type: Review
Abstract: Head and neck squamous cell carcinomas (HNSCCs) are aggressive and clinically challenging tumours that require a multidisciplinary management approach. Despite significant therapy improvements, HNSCC patients have a poor prognosis with a 5-year survival rate of about 65%. As recently recognised key players in cancer, exosomes are extracellular vesicles (EVs) with a diameter of nearly 50-120 nm which transport information from one cell to another. Exosomes are actively involved in various aspects of tumour initiation, development, metastasis, immune regulation, therapy resistance, and therapeutic applications. However, current knowledge of the role of exosomes in the pathophysiological processes of HNSCC is still in its infancy, and additional studies are needed. In this review, we summarise and discuss the relevance of exosomes in mediating local immunosuppression and therapy resistance of HNSCC. We also review the most recent studies that have explored the therapeutic potential of exosomes as cancer vaccines, drug carriers or tools to reverse the drug resistance of HNSCC.
Keywords: *Cancer Vaccines; Drug Carriers; *Exosomes/pathology; *Head and Neck Neoplasms/drug therapy/genetics/pathology; Humans; Squamous Cell Carcinoma of Head and Neck/drug therapy; Drug delivery; Exosomes; Hnscc; Head and neck cancer; Immune modulation; Immunotherapy; Therapy resistance; Vaccines
Department(s): Laboratory Research
PubMed ID: 36028150
Publisher's Version: https://doi.org/10.1016/j.bbcan.2022.188784
Terms of Use/Rights Notice: Refer to copyright notice on published article.

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