COVID-19 in children. II: Pathogenesis, disease spectrum and management

Howard-Jones, AR; Burgner, DP; Crawford, NW; Goeman, E; Gray, PE; Hsu, P; Kuek, S; McMullan, BJ; Tosif, S; Wurzel, D; Bowen, AC; Danchin, M; Koirala, A; Sharma, K; Yeoh, DK; Britton, PN

Author(s): Howard-Jones, AR; Burgner, DP; Crawford, NW; Goeman, E; Gray, PE; Hsu, P; Kuek, S; McMullan, BJ; Tosif, S; Wurzel, D; Bowen, AC; Danchin, M; Koirala, A; Sharma, K; Yeoh, DK; Britton, PN;
Details: Publication Year 2022-01,Volume 58,Issue #1,Page 46-53
Journal Title: Journal of Paediatrics and Child Health
Publication Type: Review
Abstract: The global disruption of the COVID-19 pandemic has impacted the life of every child either directly or indirectly. This review explores the pathophysiology, immune response, clinical presentation and treatment of COVID-19 in children, summarising the most up-to-date data including recent developments regarding variants of concern. The acute infection with SARS-CoV-2 is generally mild in children, whilst the post-infectious manifestations, including paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and 'long COVID' in children, are more complex. Given that most research on COVID-19 has focused on adult cohorts and that clinical manifestations, treatment availability and impacts differ markedly in children, research that specifically examines COVID-19 in children needs to be prioritised.
Keywords: *COVID-19/complications; Child; Humans; Pandemics; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Post-Acute COVID-19 Syndrome; Covid-19; Pims-ts; management; virology
Department(s): Infectious Diseases
PubMed ID: 34694037
Publisher's Version: https://doi.org/10.1111/jpc.15811
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-12-13 01:54:57

Last Modified: 2024-12-13 01:56:10