E-cadherin in developing murine T cells controls spindle alignment and progression through beta-selection
- Author(s)
- Charnley, M; Allam, AH; Newton, LM; Humbert, PO; Russell, SM;
- Details
- Publication Year 2023-01-18,Volume 9,Issue #3,Page eade5348
- Journal Title
- Science Advances
- Publication Type
- Research article
- Abstract
- A critical stage of T cell development is beta-selection; at this stage, the T cell receptor beta (TCRbeta) chain is generated, and the developing T cell starts to acquire antigenic specificity. Progression through beta-selection is assisted by low-affinity interactions between the nascent TCRbeta chain and peptide presented on stromal major histocompatibility complex and cues provided by the niche. In this study, we identify a cue within the developing T cell niche that is critical for T cell development. E-cadherin mediates cell-cell interactions and influences cell fate in many developmental systems. In developing T cells, E-cadherin contributed to the formation of an immunological synapse and the alignment of the mitotic spindle with the polarity axis during division, which facilitated subsequent T cell development. Collectively, these data suggest that E-cadherin facilitates interactions with the thymic niche to coordinate the beta-selection stage of T cell development.
- Publisher
- American Association for the Advancement of Science
- Keywords
- Animals; Mice; *Cadherins/metabolism; Cell Communication; Receptors, Antigen, T-Cell, alpha-beta; *T-Lymphocytes/cytology/metabolism; Thymus Gland; Spindle Apparatus/metabolism
- Department(s)
- Laboratory Research
- PubMed ID
- 36652509
- Publisher's Version
- https://doi.org/10.1126/sciadv.ade5348
- Open Access at Publisher's Site
10.1126/sciadv.ade5348- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-04-04 06:09:40
Last Modified: 2024-07-10 08:31:53