E-cadherin in developing murine T cells controls spindle alignment and progression through beta-selection
Details
Publication Year 2023-01-18,Volume 9,Issue #3,Page eade5348
Journal Title
Science Advances
Publication Type
Research article
Abstract
A critical stage of T cell development is beta-selection; at this stage, the T cell receptor beta (TCRbeta) chain is generated, and the developing T cell starts to acquire antigenic specificity. Progression through beta-selection is assisted by low-affinity interactions between the nascent TCRbeta chain and peptide presented on stromal major histocompatibility complex and cues provided by the niche. In this study, we identify a cue within the developing T cell niche that is critical for T cell development. E-cadherin mediates cell-cell interactions and influences cell fate in many developmental systems. In developing T cells, E-cadherin contributed to the formation of an immunological synapse and the alignment of the mitotic spindle with the polarity axis during division, which facilitated subsequent T cell development. Collectively, these data suggest that E-cadherin facilitates interactions with the thymic niche to coordinate the beta-selection stage of T cell development.
Publisher
American Association for the Advancement of Science
Keywords
Animals; Mice; *Cadherins/metabolism; Cell Communication; Receptors, Antigen, T-Cell, alpha-beta; *T-Lymphocytes/cytology/metabolism; Thymus Gland; Spindle Apparatus/metabolism
Department(s)
Laboratory Research
PubMed ID
36652509
Open Access at Publisher's Site
10.1126/sciadv.ade5348
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-04-04 06:09:40
Last Modified: 2024-07-10 08:31:53

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