Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry
Details
Publication Year 2023-03,Volume 128,Issue #7,Page 1360-1368
Journal Title
British Journal of Cancer
Publication Type
Research article
Abstract
BACKGROUND: Risk-assessment of endometrial cancer (EC) is based on clinicopathological factors and molecular subgroup. It is unclear whether adding hormone receptor expression, L1CAM expression or CTNNB1 status yields prognostic refinement. METHODS: Paraffin-embedded tumour samples of women with high-risk EC (HR-EC) from the PORTEC-3 trial (n = 424), and a Dutch prospective clinical cohort called MST (n = 256), were used. All cases were molecularly classified. Expression of L1CAM, ER and PR were analysed by whole-slide immunohistochemistry and CTNNB1 mutations were assessed with a next-generation sequencing. Kaplan-Meier method, log-rank tests and Cox's proportional hazard models were used for survival analysis. RESULTS: In total, 648 HR-EC were included. No independent prognostic value of ER, PR, L1CAM, and CTNNB1 was found, while age, stage, and adjuvant chemotherapy had an independent impact on risk of recurrence. Subgroup-analysis showed that only in NSMP HR-EC, ER-positivity was independently associated with a reduced risk of recurrence (HR 0.33, 95%CI 0.15-0.75). CONCLUSIONS: We confirmed the prognostic impact of the molecular classification, age, stage, and adjuvant CTRT in a large cohort of high-risk EC. ER-positivity is a strong favourable prognostic factor in NSMP HR-EC and identifies a homogeneous subgroup of NSMP tumours. Assessment of ER status in high-risk NSMP EC is feasible in clinical practice and could improve risk stratification and treatment.
Publisher
Springer Nature
Keywords
Female; Humans; Prognosis; Receptors, Estrogen; Immunohistochemistry; *Neural Cell Adhesion Molecule L1/metabolism; Prospective Studies; *Endometrial Neoplasms/pathology; Biomarkers, Tumor/genetics/analysis
Department(s)
Radiation Oncology; Medical Oncology
PubMed ID
36690721
Open Access at Publisher's Site
https://doi.org/10.1038/s41416-023-02141-0
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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