Evolving Practice and Outcomes in Grade 2 Glioma: Real-World Data from a Multi-Institutional Registry
- Author(s)
- Gately, L; Drummond, K; Dowling, A; Bennett, I; Freilich, R; Phillips, C; Ahern, E; Campbell, D; Dumas, M; Campbell, R; Harrup, R; Kim, GY; Reeves, S; Collins, IM; Gibbs, P;
- Details
- Publication Year 2024-10-17,Volume 16,Issue #20,Page 3514
- Journal Title
- Cancers
- Publication Type
- Research article
- Abstract
- Background: Grade-2 gliomas (G2-glioma) are uncommon. In 2016, RTOG9802 established the addition of chemotherapy after radiation (CRT) as a new standard of care for patients with high-risk G2-glioma, defined as subtotal resection or age ≥40 yrs. Here, we report current practices using real-world data. Methods: Patients diagnosed with G2-glioma from 1 January 2016 to 31 December 2022 were identified in BRAIN, a prospective clinical registry collecting data on patients with brain tumours. High- and low-risk were defined as per RTOG9802. Two time periods, January 2016-December 2019 (TP1) and January 2020-December 2022 (TP2), were defined. Survival was estimated using the Kaplan-Meier method. Results: 224 patients were identified. Overall, 38 (17%) were low-risk, with 35 (91%) observed without further treatment. A total of 186 (83%) were high-risk, with 96 (52%) observed, 63 (34%) receiving CRT, and 19 (10%) receiving radiation. Over time, CRT use increased (TP1 vs. TP2: 22% vs. 36%, p = 0.004), and the rate of biopsy (TP1 vs. TP2: 35% vs. 20%, p = 0.02) and radiotherapy alone (TP1 vs. TP2: 14% vs. 4%, p = 0.01) decreased. Median progression-free survival (PFS) was significantly longer in high-risk patients who received CRT (NR) over observation (39 months) (HR 0.49, p = 0.007). In high-risk patients who were observed, 59 (61%) were progression-free at 12 months and 10 (10%) at 5 years. OS data remains immature. Conclusions: Congruent with RTOG9802, real-world BRAIN data shows CRT is associated with improved PFS compared to observation in high-risk G2-glioma. Whilst CRT use has increased over time, observation after surgery remains the most common strategy, with some high-risk patients achieving clinically meaningful PFS. Validated biomarkers are urgently required to better inform patient management.
- Publisher
- MDPI
- Keywords
- IDH mutation; glioma; patterns of care; real-world data
- Department(s)
- Radiation Oncology
- Publisher's Version
- https://doi.org/10.3390/cancers16203514
- Open Access at Publisher's Site
https://doi.org/10.3390/cancers16203514- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-11-28 05:45:47
Last Modified: 2024-11-28 06:29:14