Radio-opaque contrast agents for liver cancer targeting with KIM during radiation therapy (ROCK-RT): an observational feasibility study

Plant, N; Mylonas, A; Sengupta, C; Nguyen, DT; Silvester, S; Pryor, D; Greer, P; Lee, YYD; Ramachandran, P; Seshadri, V; Trada, Y; Khor, R; Wang, T; Hardcastle, N; Keall, P

Author(s): Plant, N; Mylonas, A; Sengupta, C; Nguyen, DT; Silvester, S; Pryor, D; Greer, P; Lee, YYD; Ramachandran, P; Seshadri, V; Trada, Y; Khor, R; Wang, T; Hardcastle, N; Keall, P;
Details: Publication Year 2024-10-08,Volume 19,Issue #1,Page 139
Journal Title: Radiation Oncology
Publication Type: Research article
Abstract: BACKGROUND: This observational study aims to establish the feasibility of using x-ray images of radio-opaque chemoembolisation deposits in patients as a method for real-time image-guided radiation therapy of hepatocellular carcinoma. METHODS: This study will recruit 50 hepatocellular carcinoma patients who have had or will have stereotactic ablative radiation therapy and have had transarterial chemoembolisation with a radio-opaque agent. X-ray and computed tomography images of the patients will be analysed retrospectively. Additionally, a deep learning method for real-time motion tracking will be developed. We hypothesise that: (i) deep learning software can be developed that will successfully track the contrast agent mass on two thirds of cone beam computed tomography (CBCT) projection and intra-treatment images (ii), the mean and standard deviation (mm) difference in the location of the mass between ground truth and deep learning detection are ≤ 2 mm and ≤ 3 mm respectively and (iii) statistical modelling of study data will predict tracking success in 85% of trial participants. DISCUSSION: Developing a real-time tracking method will enable increased targeting accuracy, without the need for additional invasive procedures to implant fiducial markers. TRIAL REGISTRATION: Registered to ClinicalTrials.gov (NCT05169177) 12th October 2021.
Publisher: BioMed Central
Keywords: Humans; *Liver Neoplasms/radiotherapy/diagnostic imaging; *Feasibility Studies; *Contrast Media; *Carcinoma, Hepatocellular/radiotherapy/diagnostic imaging; *Radiotherapy, Image-Guided/methods; Retrospective Studies; Cone-Beam Computed Tomography/methods; Male; Female; Radiotherapy Planning, Computer-Assisted/methods; Chemoembolization, Therapeutic/methods; Radiosurgery/methods; Image Guidance; Kilovoltage Intrafraction Monitoring; Liver; Neoplasms; Radio-opaque contrast; Radiotherapy; Stereotactic ablative Radiation Therapy (SABR); Transarterial chemoemobilisation (TACE)
Department(s): Physical Sciences
Publisher's Version: https://doi.org/10.1186/s13014-024-02524-4
Open Access at Publisher's Site: https://doi.org/10.1186/s13014-024-02524-4
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-11-07 06:46:44

Last Modified: 2024-11-07 06:54:52