Epigenetic Modifications in Lymphoma and Their Role in the Classification of Lymphomas
- Author(s)
- Harrop, S; Yannakou, CK; van der Weyden, C; Prince, HM;
- Details
- Publication Year 2022,Volume 3,Issue #1,Page 174-187
- Journal Title
- Hemato
- Publication Type
- Review
- Abstract
- The characterisation of the lymphoma epigenome has provided insight into mechanisms involved in lymphomagenesis. Multiple lymphoma subtypes demonstrate recurrent mutations in key epigenetic regulators that have been utilised to define clinicogenetic groups that can predict clinical behaviour in these heterogenous entities. The high frequency of mutations in epigenetic regulators provides rationale to incorporate these in the classification of some subtypes of lymphoma. In addition, their recurrent nature provides a rationale to target such mutations, or the relevant pathway, for treatment. In this review, we summarised the available literature on epigenetic dysregulation in lymphoma and how it has been utilised in diagnosis and classification.
- Keywords
- lymphomagenesis; methylation; histone modification
- Department(s)
- Haematology
- Publisher's Version
- https://doi.org/10.3390/hemato3010015
- Open Access at Publisher's Site
https://doi.org/10.3390/hemato3010015- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-11-01 04:30:27
Last Modified: 2024-11-01 04:31:35