Targeted liver ultrasound performed by an expert is the pivotal imaging examination for low phospholipid-associated cholelithiasis
- Author(s)
- Su, S; Trinh, A; Metz, AJ; Speer, T; Simkin, P; Buchanan, D; Boussioutas, A; Gibson, R;
- Details
- Publication Year 2023-03-01,Volume 35,Issue #3,Page 327-332
- Journal Title
- European Journal of Gastroenterology & Hepatology
- Publication Type
- Research article
- Abstract
- OBJECTIVES: Low phospholipid-associatedcholelithiasis (LPAC) is a clinical syndrome that can be associated with variants in the adenosinetriphosphate-binding cassette subfamily B, member 4 (ABCB4) transporter gene, in a proportion of patients. The diagnosis of LPAC is defined by clinical as well as imaging criteria of intrahepatic hyperechoic foci or microlithiasis and biliary sludge on ultrasound. The aim of the study was to assess the role of imaging in investigating patients presenting with clinical features suggesting a diagnosis of LPAC. METHODS: Imaging findings in 51 patients with clinical LPAC were retrospectively reviewed. Most patients had been referred with difficult-to-manage biliary pain postcholecystectomy and some with intrahepatic dilated ducts and stones. The diagnosis of LPAC was made on clinical features. RESULTS: The patients were young with symptom onset at median age 24 years and were mainly female (75%). Ultrasound was performed by an expert in 48/51 and magnetic resonance cholangiopancreatography (MRCP) in 47/51 patients. Targeted liver ultrasound found small hyperechoic foci with comet tail artifacts or posterior acoustic shadowing typical of LPAC in 30/48 (63%) of examinations. However, ultrasound examinations performed before referral for investigation did not report these findings. Intrahepatic duct dilatation was seen in 26/51 (51%) of cases. MRCP did not reliably detect microlithiasis. CONCLUSIONS: Targeted liver ultrasound performed by an expert aware of the possible diagnosis is the pivotal investigation for patients with clinical features suggesting LPAC. The findings in ultrasound performed before referral suggest LPAC is under-recognized and under-diagnosed.
- Publisher
- Wolters Kluwer
- Keywords
- Female; Humans; Male; Young Adult; ATP Binding Cassette Transporter, Subfamily B/genetics; *Cholelithiasis/diagnostic imaging; Liver/diagnostic imaging; Phospholipids; Retrospective Studies
- Department(s)
- Surgical Oncology
- PubMed ID
- 36708304
- Publisher's Version
- https://doi.org/10.1097/MEG.0000000000002492
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-07-11 06:23:36
Last Modified: 2023-07-11 06:25:37