Diagnosis, management and follow up of peripheral T-cell lymphomas: a consensus practice statement from the Australasian Lymphoma Alliance
- Author(s)
- Hapgood, G; Latimer, M; Lee, ST; Kuss, B; Lade, S; Tobin, JWD; Purtill, D; Campbell, BA; Prince, HM; Hawkes, EA; Shortt, J; Radeski, D;
- Details
- Publication Year 2022-10,Volume 52,Issue #10,Page 1806-1817
- Journal Title
- Internal Medicine Journal
- Publication Type
- Guideline
- Abstract
- Peripheral T-cell lymphomas (PTCL) represent a heterogeneous disease group accounting for 10% of non-Hodgkin lymphomas. PTCL patients have typically poorer outcomes compared with aggressive B-cell lymphomas. However, such outcomes are heavily dependent on subtype. Although anthracycline-based regimens such as cyclophosphamide, doxorubicin, vincristine and prednisone remain the standard first-line treatment for most aggressive PTCL, there are important variations including incorporation of novel agents, use of radiotherapy and judicious consideration of stem cell transplantation. Relapsed or refractory disease represents a significant area of unmet need where chemotherapy intensification has limited efficacy and novel agents such as brentuximab vedotin and pralatrexate provide additional opportunities for attainment of remission and potential stem cell transplant. In the future, pre-therapy prognostic biomarkers including genomic characterisation, may aid in risk stratification and help guide initial patient management to improve survival. There is an urgent need to understand better the pathogenesis of PTCL to facilitate novel drug combinatorial approaches to improve survival. This position statement represents an evidence-based synthesis of the literature for application in Australian and New Zealand practice.
- Keywords
- Humans; *Lymphoma, T-Cell, Peripheral/diagnosis/therapy; Vincristine/therapeutic use; Brentuximab Vedotin; Prednisone; Consensus; Follow-Up Studies; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Australia/epidemiology; Cyclophosphamide/therapeutic use; Doxorubicin/therapeutic use; Biomarkers; Aitl; Alcl; Ptcl; chemotherapy; peripheral T-cell lymphoma
- Department(s)
- Pathology; Radiation Oncology; Haematology
- PubMed ID
- 34668281
- Publisher's Version
- https://doi.org/10.1111/imj.15595
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-11-01 04:13:52
Last Modified: 2024-11-01 04:19:47