Utility of Cytomegalovirus Cell-Mediated Immunity Assays in Solid Organ Transplantation
- Details
- Publication Year 2022-08-17,Volume 60,Issue #8,Page e01716-21
- Journal Title
- Journal of Clinical Microbiology
- Publication Type
- Review
- Abstract
- Cytomegalovirus (CMV) is one of the most important viral complications after solid organ transplantation (SOT). Current preventive and management strategies rely primarily on serologic and viral load testing and remain suboptimal. To address these issues, multiple techniques to measure CMV-specific cell-mediated immunity (CMI) have been developed and evaluated in clinical studies over the past two decades. These assays show significant promise for the personalization of CMV management. For example, CMI assays can be used to help determine the optimal duration of antiviral prophylaxis or whether antiviral therapy is indicated in patients with low levels of CMV reactivation. However, despite numerous studies showing potential utility, these assays are not yet in widespread routine clinical use. Barriers to adoption include variations in test complexity, standardization, and thresholds for positivity and insufficient interventional clinical trials. Here, we provide an updated assessment of commonly available tests and the clinical utility of CMV-specific CMI testing in SOT recipients.
- Keywords
- Antiviral Agents/therapeutic use; Cytomegalovirus; *Cytomegalovirus Infections/diagnosis/prevention & control; Humans; Immunity, Cellular; *Organ Transplantation/adverse effects; cellular immunity
- Department(s)
- Infectious Diseases
- PubMed ID
- 35543099
- Publisher's Version
- https://doi.org/10.1128/jcm.01716-21
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-11-01 04:13:48
Last Modified: 2024-11-01 04:19:47