Management of atopic dermatitis: a narrative review
- Details
- Publication Year 2022-06-20,Volume 216,Issue #11,Page 587-593
- Journal Title
- Medical Journal of Australia
- Publication Type
- Review
- Abstract
- Atopic dermatitis (atopic eczema) is the most common inflammatory skin disease and has a significant burden on the quality of life of patients, families and caregivers. Its pathogenesis is a complex interplay between genetics and environment, involving impaired skin barrier function, immune dysregulation primarily involving the Th2 inflammatory pathway, itch, and skin microbiome. Restoration of skin barrier integrity with regular emollients and prompt topical anti-inflammatory therapies are mainstays of treatment. Systemic therapy is considered for moderate to severe disease. New understanding of inflammatory pathways and developments in targeted systemic immunotherapies have significantly advanced atopic dermatitis management. Dupilumab is a safe and effective treatment that is now available in Australia. Other promising agents for atopic dermatitis include Janus kinase, interleukin (IL)-13 and IL-31 inhibitors.
- Keywords
- *Dermatitis, Atopic/complications/drug therapy; Emollients/therapeutic use; Humans; Pruritus/drug therapy; Quality of Life; Treatment Outcome; Dermatitis; Eczema
- Department(s)
- Surgical Oncology
- PubMed ID
- 35644531
- Publisher's Version
- https://doi.org/10.5694/mja2.51560
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-31 04:55:10
Last Modified: 2024-10-31 04:56:11