Assessing the utility of routine viral surveillance performed in children undergoing autologous stem cell transplantation at a single centre

Author(s): Foley, DA; Wong, JWS; Keane, A; Ramachandran, S; Blyth, CC; Yeoh, DK;
Details: Publication Year 2022-12,Volume 69,Issue #12,Page e30012
Journal Title: Pediatric Blood & Cancer
Publication Type: Research article
Abstract: We assessed the utility of routine viral surveillance for cytomegalovirus, Epstein-Barr virus and human adenovirus in children <16 years, undergoing autologous stem cell transplantation (ASCT) at a single centre over a 10-year period. A total of 85 ASCT were performed in 65 patients. Routine viral surveillance resulted in a high number of tests performed (median 20 tests per ASCT), without any clinically significant viral detections. These data support the limited clinical utility of routine viral surveillance in children undergoing ASCT. Adopting a clinically driven approach for viral testing is likely to be both cost-effective and safe.
Keywords: Child; Humans; *Hematopoietic Stem Cell Transplantation; Transplantation, Autologous; *Cytomegalovirus Infections; *Epstein-Barr Virus Infections; Herpesvirus 4, Human; Stem Cell Transplantation/adverse effects/methods; Retrospective Studies; Epstein-Barr virus; autologous stem cell transplantation; cytomegalovirus; human adenovirus; viral surveillance
Department(s): Infectious Diseases
PubMed ID: 36129388
Publisher's Version: https://doi.org/10.1002/pbc.30012
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-10-24 06:56:10

Last Modified: 2024-10-24 06:56:36