Integrating Immunotherapy Into the Treatment Landscape for Patients With Triple-Negative Breast Cancer
- Author(s)
- Dixon-Douglas, J; Loibl, S; Denkert, C; Telli, M; Loi, S;
- Journal Title
- American Society of Clinical Oncology Educational Book
- Publication Type
- Review
- Abstract
- Triple-negative breast cancer (TNBC) is the most aggressive histologic subtype of breast cancer for which, until recently, treatment options have been limited to chemotherapy. In recent years, an improved understanding of the importance of tumor-infiltrating lymphocytes and the tumor microenvironment in TNBC has led to investigation of immune checkpoint inhibitors for treatment. There is now evidence from several randomized controlled trials that supports the addition of immune checkpoint inhibitors to first-line treatment of advanced TNBC and to neoadjuvant chemotherapy for stage II-III TNBC. In parallel, the PARP inhibitors have emerged as a targeted therapy option for patients with HER2-negative breast cancer harboring mutations in BRCA1, BRCA2, and PALB2. Here, we review the recent clinical trials that inform the integration of immune checkpoint inhibitors into treatments for TNBC and discuss ongoing challenges-including patient selection, management of resistance to post-checkpoint inhibitor therapy, and combining immunotherapy with targeted therapies, including PARP inhibitors.
- Keywords
- Humans; Immune Checkpoint Inhibitors/therapeutic use; Immunotherapy; Neoadjuvant Therapy; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; *Triple Negative Breast Neoplasms/drug therapy/genetics; Tumor Microenvironment
- Department(s)
- Medical Oncology; Laboratory Research
- PubMed ID
- 35649211
- Publisher's Version
- https://doi.org/10.1200/EDBK_351186
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-24 01:11:57
Last Modified: 2024-10-24 01:14:10