Deciphering breast cancer: from biology to the clinic
- Author(s)
- Nolan, E; Lindeman, GJ; Visvader, JE;
- Details
- Publication Year 2023-04-13,Volume 186,Issue #8,Page 1708-1728
- Journal Title
- Cell
- Publication Type
- Review
- Abstract
- Breast cancer remains a leading cause of cancer-related mortality in women, reflecting profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last decade, genomic and transcriptomic data have been integrated on an unprecedented scale and revealed distinct cancer subtypes, critical molecular drivers, clonal evolutionary trajectories, and prognostic signatures. Furthermore, multi-dimensional integration of high-resolution single-cell and spatial technologies has highlighted the importance of the entire breast cancer ecosystem and the presence of distinct cellular "neighborhoods." Clinically, a plethora of new targeted therapies has emerged, now being rapidly incorporated into routine care. Resistance to therapy, however, remains a crucial challenge for the field.
- Publisher
- Cell Press
- Keywords
- Female; Humans; *Breast Neoplasms/pathology/therapy; Gene Expression Profiling; Genomics; Transcriptome; Drug Resistance, Neoplasm
- Department(s)
- Medical Oncology
- PubMed ID
- 36931265
- Publisher's Version
- https://doi.org/10.1016/j.cell.2023.01.040
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-06-27 07:59:05
Last Modified: 2023-06-27 07:59:22