Deciphering breast cancer: from biology to the clinic
Details
Publication Year 2023-04-13,Volume 186,Issue #8,Page 1708-1728
Journal Title
Cell
Publication Type
Review
Abstract
Breast cancer remains a leading cause of cancer-related mortality in women, reflecting profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last decade, genomic and transcriptomic data have been integrated on an unprecedented scale and revealed distinct cancer subtypes, critical molecular drivers, clonal evolutionary trajectories, and prognostic signatures. Furthermore, multi-dimensional integration of high-resolution single-cell and spatial technologies has highlighted the importance of the entire breast cancer ecosystem and the presence of distinct cellular "neighborhoods." Clinically, a plethora of new targeted therapies has emerged, now being rapidly incorporated into routine care. Resistance to therapy, however, remains a crucial challenge for the field.
Publisher
Cell Press
Keywords
Female; Humans; *Breast Neoplasms/pathology/therapy; Gene Expression Profiling; Genomics; Transcriptome; Drug Resistance, Neoplasm
Department(s)
Medical Oncology
PubMed ID
36931265
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-06-27 07:59:05
Last Modified: 2023-06-27 07:59:22

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