Seprafilm&#174; and adhesive small bowel obstruction in colorectal/abdominal surgery: an updated systematic review

Choy, KT; Le, KDR; Kong, JCH

Seprafilm® and adhesive small bowel obstruction in colorectal/abdominal surgery: an updated systematic review

Author(s): Choy, KT; Le, KDR; Kong, JCH;
Details: Publication Year 2024-10-05,Volume 24,Issue #1,Page 291
Journal Title: BMC Surgery
Publication Type: Research article
Abstract: BACKGROUND: The efficacy of Seprafilm(®) in preventing clinically significant adhesive small bowel obstruction (ASBO) is controversial and deserves further review. The aim of this review was to assess the utility of Seprafilm(®) in preventing clinically significant adhesive bowel obstruction after abdominal operations, with separate focus on colorectal resections. The secondary aim was to provide an updated literature review on the safety profile of this implant. METHODS: An up-to-date systematic review was performed on the available literature between 2000 and 2023 on PubMed, EMBASE, Medline, and Cochrane Library databases. The main outcome measures were rates of adhesive bowel obstruction, as well as rates of intervention. The secondary outcome was the clinical safety profile of Seprafilm(®) as described in current literature. RESULTS: A total of 17 observational studies were included, accounting for 62,886 patients. Use of Seprafilm(®) was associated with a significant reduction in adhesive bowel obstruction events (OR 0.449, 95% CI: 0.3271 to 0.6122, p < 0.001), with preserved efficacy seen in laparoscopic cases. This did not translate into a reduced rate of reintervention. Clinicians should also be aware of isolated reports of a paradoxical inflammatory reaction leading to fluid collections after Seprafilm(®) use, although they appear uncommon. CONCLUSION: Seprafilm(®) can be considered in select patients although further study to determine which patients will benefit most is required.
Publisher: BioMed Central
Keywords: Humans; *Intestinal Obstruction/etiology; *Hyaluronic Acid/administration & dosage/adverse effects; Tissue Adhesions/prevention & control/etiology; *Postoperative Complications/etiology/epidemiology/prevention & control; *Intestine, Small; Abdomen/surgery; Abdominal surgeries; Adhesive small bowel obstruction; Colorectal; Seprafilm®
Department(s): Surgical Oncology
Publisher's Version: https://doi.org/10.1186/s12893-024-02581-2
Open Access at Publisher's Site: https://doi.org/10.1186/s12893-024-02581-2
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-10-23 03:01:04

Last Modified: 2024-10-23 03:12:18