Robust SARS-CoV-2 T cell responses with common TCRalphabeta motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells
Details
Publication Year 2023-04-18,Volume 4,Issue #4,Page 101017
Journal Title
Cell Reports Medicine
Publication Type
Research article
Abstract
Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 vaccine doses. We evaluated immune responses in hematology patients across three COVID-19 vaccination doses. Seropositivity was low after a first dose of BNT162b2 and ChAdOx1 ( approximately 26%), increased to 59%-75% after a second dose, and increased to 85% after a third dose. While prototypical antibody-secreting cells (ASCs) and T follicular helper (Tfh) cell responses were elicited in healthy participants, hematology patients showed prolonged ASCs and skewed Tfh2/17 responses. Importantly, vaccine-induced expansions of spike-specific and peptide-HLA tetramer-specific CD4(+)/CD8(+) T cells, together with their T cell receptor (TCR) repertoires, were robust in hematology patients, irrespective of B cell numbers, and comparable to healthy participants. Vaccinated patients with breakthrough infections developed higher antibody responses, while T cell responses were comparable to healthy groups. COVID-19 vaccination induces robust T cell immunity in hematology patients of varying diseases and treatments irrespective of B cell numbers and antibody response.
Publisher
Cell Press
Keywords
Humans; Receptors, Antigen, T-Cell, alpha-beta; COVID-19 Vaccines; SARS-CoV-2; BNT162 Vaccine; CD8-Positive T-Lymphocytes; *covid-19; *Hematologic Neoplasms; B cells; CD4(+) T cells; CD8(+) T cells; T follicular helper cells; antibody-secreting cells; hematology; memory T cells; tetramer-specific
Department(s)
Infectious Diseases; Clinical Haematology
PubMed ID
37030296
Open Access at Publisher's Site
https://doi.org/10.1016/j.xcrm.2023.101017
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-06-27 07:59:04
Last Modified: 2023-06-27 07:59:22

© 2024 The Walter and Eliza Hall Institute of Medical Research. Access to this website is subject to our Privacy Policy and Terms of Use

An error has occurred. This application may no longer respond until reloaded. Reload 🗙