Robust SARS-CoV-2 T cell responses with common TCRalphabeta motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells

Nguyen, THO; Rowntree, LC; Allen, LF; Chua, BY; Kedzierski, L; Lim, C; Lasica, M; Tennakoon, GS; Saunders, NR; Crane, M; Chee, L; Seymour, JF; Anderson, MA; Whitechurch, A; Clemens, EB; Zhang, W; Chang, SY; Habel, JR; Jia, X; McQuilten, HA; Minervina, AA; Pogorelyy, MV; Chaurasia, P; Petersen, J; Menon, T; Hensen, L; Neil, JA; Mordant, FL; Tan, HX; Cabug, AF; Wheatley, AK; Kent, SJ; Subbarao, K; Karapanagiotidis, T; Huang, H; Vo, LK; Cain, NL; Nicholson, S; Krammer, F; Gibney, G; James, F; Trevillyan, JM; Trubiano, JA; Mitchell, J; Christensen, B; Bond, KA; Williamson, DA; Rossjohn, J; Crawford, JC; Thomas, PG; Thursky, KA; Slavin, MA; Tam, CS; Teh, BW; Kedzierska, K

Author(s): Nguyen, THO; Rowntree, LC; Allen, LF; Chua, BY; Kedzierski, L; Lim, C; Lasica, M; Tennakoon, GS; Saunders, NR; Crane, M; Chee, L; Seymour, JF; Anderson, MA; Whitechurch, A; Clemens, EB; Zhang, W; Chang, SY; Habel, JR; Jia, X; McQuilten, HA; Minervina, AA; Pogorelyy, MV; Chaurasia, P; Petersen, J; Menon, T; Hensen, L; Neil, JA; Mordant, FL; Tan, HX; Cabug, AF; Wheatley, AK; Kent, SJ; Subbarao, K; Karapanagiotidis, T; Huang, H; Vo, LK; Cain, NL; Nicholson, S; Krammer, F; Gibney, G; James, F; Trevillyan, JM; Trubiano, JA; Mitchell, J; Christensen, B; Bond, KA; Williamson, DA; Rossjohn, J; Crawford, JC; Thomas, PG; Thursky, KA; Slavin, MA; Tam, CS; Teh, BW; Kedzierska, K;
Details: Publication Year 2023-04-18,Volume 4,Issue #4,Page 101017
Journal Title: Cell Reports Medicine
Publication Type: Research article
Abstract: Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 vaccine doses. We evaluated immune responses in hematology patients across three COVID-19 vaccination doses. Seropositivity was low after a first dose of BNT162b2 and ChAdOx1 ( approximately 26%), increased to 59%-75% after a second dose, and increased to 85% after a third dose. While prototypical antibody-secreting cells (ASCs) and T follicular helper (Tfh) cell responses were elicited in healthy participants, hematology patients showed prolonged ASCs and skewed Tfh2/17 responses. Importantly, vaccine-induced expansions of spike-specific and peptide-HLA tetramer-specific CD4(+)/CD8(+) T cells, together with their T cell receptor (TCR) repertoires, were robust in hematology patients, irrespective of B cell numbers, and comparable to healthy participants. Vaccinated patients with breakthrough infections developed higher antibody responses, while T cell responses were comparable to healthy groups. COVID-19 vaccination induces robust T cell immunity in hematology patients of varying diseases and treatments irrespective of B cell numbers and antibody response.
Publisher: Cell Press
Keywords: Humans; Receptors, Antigen, T-Cell, alpha-beta; COVID-19 Vaccines; SARS-CoV-2; BNT162 Vaccine; CD8-Positive T-Lymphocytes; *covid-19; *Hematologic Neoplasms; B cells; CD4(+) T cells; CD8(+) T cells; T follicular helper cells; antibody-secreting cells; hematology; memory T cells; tetramer-specific
Department(s): Infectious Diseases; Clinical Haematology
PubMed ID: 37030296
Publisher's Version: https://doi.org/10.1016/j.xcrm.2023.101017
Open Access at Publisher's Site: https://doi.org/10.1016/j.xcrm.2023.101017
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-06-27 07:59:04

Last Modified: 2023-06-27 07:59:22