Enzalutamide in metastatic hormone-sensitive prostate cancer: A plain language summary of the ARCHES and ENZAMET follow-up studies

Armstrong, AJ; Azad, AA; Conduit, C; Haas, GP; Bland, C; Davis, ID

Author(s): Armstrong, AJ; Azad, AA; Conduit, C; Haas, GP; Bland, C; Davis, ID;
Details: Publication Year 2025-10-15,Volume 21,Issue #1,Page 15-24
Journal Title: Future Oncology
Publication Type: Commentary
Abstract: WHAT IS THIS SUMMARY ABOUT? This summary includes information from the ARCHES and ENZAMET follow-up studies. Both studies looked at enzalutamide treatment for people with metastatic hormone-sensitive prostate cancer (known as mHSPC). In ARCHES, researchers compared the medications enzalutamide + androgen deprivation therapy (known as ADT) with placebo + ADT. In ENZAMET, researchers compared enzalutamide + ADT with standard treatment + ADT. Some people in ENZAMET also took enzalutamide with docetaxel (a chemotherapy treatment). In both studies, researchers wanted to find out if enzalutamide helps people with mHSPC live longer. WHAT ARE THE KEY TAKEAWAYS? In both studies, researchers found that people with mHSPC who took enzalutamide lived longer than people who did not. People who took enzalutamide also lived longer without their cancer getting worse. The results were mostly similar in groups of people dependingon when and where their cancer was found. Researchers did not find any new safety concerns. WHAT WERE THE MAIN CONCLUSIONS? People with mHSPC may benefit from long-term treatment with enzalutamide + ADT. They may also benefit from taking enzalutamide with other treatments, like docetaxel. It may be better for people with mHSPC to have enzalutamide treatment before their cancer gets worse, rather than waiting. These people and their doctors should carefully consider the benefits and risks of each treatment to make a joint decision for treating mHSPC.Clinical Trial Registration: NCT02677896 (ARCHES), NCT02446405 (ENZAMET) (ClinicalTrials.gov).
Publisher: Taylor & Francis
Keywords: docetaxel; enzalutamide; lay summary; metastatic castration-sensitive prostate cancer; metastatic hormone-sensitive prostate cancer; novel hormonal therapy; plain language summary; urologic/prostate
Department(s): Medical Oncology
Publisher's Version: https://doi.org/10.1080/14796694.2024.2408101
Open Access at Publisher's Site: https://doi.org/10.1080/14796694.2024.2408101
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-10-22 06:20:33

Last Modified: 2025-01-28 06:44:39