Functional outcomes after lateral pelvic lymph node dissection for rectal cancer: a systematic review and meta-analysis

Cribb, BI; Kong, J; McCormick, J; Warrier, SK; Heriot, AG

Author(s): Cribb, BI; Kong, J; McCormick, J; Warrier, SK; Heriot, AG;
Details: Publication Year 2022-03,Volume 37,Issue #3,Page 583-595
Journal Title: International Journal of Colorectal Disease
Publication Type: Review
Abstract: PURPOSE: Lateral pelvic lymph node dissection (LPLND) may improve oncological outcomes for select patients with rectal cancer, though functional outcomes may be adversely impacted. The aim of this study is to assess the functional outcomes associated with LPLND for rectal cancer and compare these outcomes with standard surgical resection. METHODS: A systematic search was undertaken to identify relevant studies reporting on urinary dysfunction (UD), sexual dysfunction (SD), and defecatory dysfunction (DD) for patients who underwent LPLND for rectal cancer. Studies comparing functional outcomes in patients who underwent surgery with and without LPLND were assessed. In addition, a comparison of functional outcomes in patients who underwent LPLND before and after the year 2000 was performed. RESULTS: Twenty-one studies of predominantly non-randomised observational data were included. Ten were comparative studies. Male SD was worse in patients who underwent LPLND compared with those who did not (RR 1.68 (95% CI 1.41-1.99, P < 0.001)). No difference was observed for the rate of UD between treatment groups. The rates of UD and male SD in patients who underwent LPLND after the year 2000 were significantly lower than those who underwent LPLND before the year 2000 ((UD) RR = 4.5, p value = 0.0034; male SD RR = 28.7, p value < 0.001). CONCLUSION: Lateral pelvic lymph node dissection is associated with worse male sexual dysfunction compared to standard surgical resection. However, the rates of urine dysfunction and male sexual dysfunction are better in contemporary cohorts which may reflect improved surgical technique and autonomic nerve preservation.
Keywords: Humans; Lymph Node Excision/adverse effects/methods; Lymph Nodes/pathology; Male; *Neoadjuvant Therapy; Neoplasm Recurrence, Local/surgery; Pelvis/pathology/surgery; *Rectal Neoplasms/pathology; Retrospective Studies; Treatment Outcome; Extended lymphadenectomy; Functional outcomes; Lateral pelvic lymph node dissection; Rectal adenocarcinoma
Department(s): Surgical Oncology
PubMed ID: 34846550
Publisher's Version: https://doi.org/10.1007/s00384-021-04073-8
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-10-18 05:06:13

Last Modified: 2024-10-18 05:07:17